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Updated: Aug 14, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Prothrombotic disorders and ischemic stroke in children

A K Chan1, G deVeber

  • 1University of Toronto, Department of Paediatrics, Hospital for Sick Children, Ontario, Canada.

Seminars in Pediatric Neurology
|February 24, 2001
PubMed

Insights

Childhood stroke, including arterial ischemic stroke and sinovenous thrombosis, is often linked to prothrombotic disorders. Screening children with stroke for these conditions is crucial for prevention and understanding causes.

Area of Science:

  • Pediatric Neurology
  • Hematology
  • Vascular Medicine

Background:

  • Childhood stroke, encompassing arterial ischemic stroke (AIS) and sinovenous thrombosis (SVT), is uncommon but severe.
  • Understanding the causes of pediatric stroke is vital for developing prevention strategies.
  • Prothrombotic disorders are implicated in the etiology of childhood stroke.

Purpose of the Study:

  • To review the role of prothrombotic disorders in childhood ischemic stroke.
  • To highlight the incidence of these disorders in pediatric AIS and SVT.
  • To recommend screening for prothrombotic disorders in children with stroke.

Main Methods:

  • Literature review of studies on childhood stroke and prothrombotic disorders.
  • Analysis of reported incidences of specific prothrombotic conditions.
  • Synthesis of current understanding regarding the contribution of these disorders to stroke etiology.

Main Results:

  • Prothrombotic disorders are found in 20-50% of childhood AIS and 33-99% of childhood SVT.
  • Identified disorders include deficiencies in antithrombin, protein C, S, plasminogen, Factor V Leiden, Prothrombin gene mutations, dysfibrinogenemia, antiphospholipid antibodies, hyperhomocysteinemia, and elevated lipoprotein (a).
  • Other contributing factors include hyperlipidemia, polycythemia, iron deficiency anemia, and platelet disorders.

Conclusions:

  • Prothrombotic disorders are prevalent in children with stroke and likely play a causative role.
  • Screening for these disorders in pediatric stroke patients is recommended.
  • Further research is needed to define the exact contribution of specific disorders and optimize treatment.

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