Related Experiment Videos
PFAPA syndrome (Periodic Fever, Aphthous stomatitis, Pharyngitis, Adenitis)
1Department of Pediatrics, Chang-Gung Children's Hospital and Chang Gung University, Taoyuan, Taiwan.
Clinical Rheumatology
|February 24, 2001
Summary
Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis (PFAPA) syndrome is a benign condition in children. Prompt diagnosis through clinical history and physical findings is key, with effective treatments including steroids and tonsillectomy.
Area of Science:
- Pediatrics
- Immunology
- Rheumatology
Background:
- PFAPA syndrome is a common cause of periodic fever in children.
- Early diagnosis and management are crucial for preventing complications.
Observation:
- This study presents two cases of PFAPA syndrome, one typical and one atypical.
- Literature review identified 28 typical and 2 atypical cases.
Findings:
- Typical PFAPA presents before age 5 with fever, pharyngitis, cervical adenitis, and stomatitis.
- Atypical PFAPA can occur later and may have severe complications like intestinal perforation.
Implications:
- Accurate diagnosis of PFAPA syndrome relies on detailed history and physical examination.
- Steroids and tonsillectomy are effective treatments for typical PFAPA.
- Cimetidine may be preferred over steroids in atypical PFAPA cases requiring long-term immunosuppression.