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Dimeric beta-turn peptidomimetics as ligands for the neurotrophin receptor TrkC
A J Zhang1, S Khare, K Gokulan
1Texas A&M University, Chemistry Department, College Station, TX 77842-3012, USA.
Bioorganic & Medicinal Chemistry Letters
|February 24, 2001
Abstract:
Twelve dimeric peptidomimetics 1 were prepared via a divergent-convergent strategy. These peptidomimetics incorporated the same amino acids as i +1 and i + 2 residues in key beta-turns of the neurotrophin NT-3. Cytosensor microphysiometry was used to gauge the effects of the dimers 1 on cells that overexpress the NT-3 receptor, TrkC. Increases in extracellular acidification rates were observed for some monomers 3, but the active dimers gave greater effects.