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Neonatal meningitis in England and Wales: 10 years on
D E Holt1, S Halket, J de Louvois
1The Karim Centre for Meningitis Research, Imperial College School of Medicine, Department of Paediatrics and Neonatal Medicine, Queen Charlotte's and Chelsea Hospital, Goldhawk Road, London W6 0XG, UK.
Archives of Disease in Childhood. Fetal and Neonatal Edition
|February 24, 2001
Summary
Neonatal meningitis incidence in England and Wales remains stable, but acute phase mortality has significantly decreased. This reduction in deaths from neonatal meningitis offers hope for reduced long-term fear.
Area of Science:
- Pediatrics
- Infectious Diseases
- Epidemiology
Background:
- Neonatal meningitis poses a significant threat to infants.
- Previous studies have established baseline incidence and mortality rates.
Purpose of the Study:
- To determine the current incidence of neonatal meningitis in England and Wales.
- To assess changes in mortality rates and common causative agents.
Main Methods:
- A national postal survey utilizing the British Paediatric Surveillance Unit (BPSU) card scheme.
- Data collection from 274 infants under 28 days treated for meningitis between 1996-1997.
Main Results:
- Neonatal meningitis incidence remained unchanged compared to 1985-1987.
- Acute phase mortality decreased from 19.8% to 6.6%.
- Group B streptococci and Escherichia coli were the most common pathogens; third-generation cephalosporins were frequently used.
Conclusions:
- Despite unchanged incidence, a significant reduction in neonatal meningitis mortality was observed.
- Continued improvements may reduce the long-term impact and associated parental anxiety.