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[Synthesis of protective antigens during submerged cultivation of Vibrio cholerae]
V A Fedorova1, N A Syrova, O V Gromova
1Research Institute for Plague Control Microbe, Saratov, Russia.
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|February 24, 2001
Abstract:
The effectiveness of dot immunoanalysis for evaluating the dynamics of the synthesis of O-antigen, cholera toxin, neuraminidase, adhesin CFA1 in the process of the reactor cultivation of V. cholerae used for the production of oral chemical cholera vaccine is shown. The established regularities of the synthesis of the protective antigens of V. cholerae in the process of scaled-up cultivation are discussed.