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[What do we know today about diaminodiphenylsulfone?].
Z Golusin1, M Poljacki, R Preveden
1Klinika za kozno-venericne bolesti, Medicinski fakultet, Klinicki centar, Novi Sad.
Medicinski Pregled
|February 24, 2001
Summary
Diaminodiphenylsulfone (dapsone) is an effective bacteriostatic agent for leprosy and malaria, and is now used for inflammatory skin diseases. Careful monitoring of dosage and patient parameters is crucial to balance dapsone
Area of Science:
- Pharmacology
- Dermatology
Context:
- Diaminodiphenylsulfone (dapsone), synthesized in 1908, is a bacteriostatic agent historically used for leprosy and malaria.
- Currently, dapsone is utilized for treating noninfectious inflammatory dermatologic conditions.
Purpose:
- To review the pharmacology, mechanism of action, clinical applications, and adverse effects of dapsone in dermatologic therapy.
- To highlight the importance of balancing therapeutic efficacy with potential adverse effects.
Summary:
- Dapsone inhibits folic acid synthesis in susceptible organisms, contributing to its bacteriostatic effect.
- Its anti-inflammatory properties, crucial for treating noninfectious inflammatory dermatoses, are not fully elucidated and may be independent of its antibacterial action.
- Dapsone is effective in treating conditions like dermatitis herpetiformis and erythema elevatum diutinum, with varying responses in other dermatoses.
Impact:
- Dapsone is indicated for specific dermatoses and can be employed for other inflammatory conditions by carefully managing dosage and monitoring patients.
- Understanding the dose-dependent adverse effects, such as hemolytic anemia and methemoglobinemia, is essential for safe dapsone use.
- Pre-treatment screening, including glucose-6-phosphate dehydrogenase levels, is recommended to prevent adverse reactions.