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Multidrug resistant Salmonella typhi in Rourkela, Orissa
1Department of Microbiology, Ispat General Hospital, Rourketa.
Indian Journal of Pathology & Microbiology
|February 24, 2001
Summary
Multidrug-resistant Salmonella typhi strains are a growing concern in Rourkela, though chloramphenicol and ceftriaxone remain effective treatments. This study highlights the need for judicious antibiotic use to combat emerging resistance patterns in enteric fever.
Area of Science:
- Microbiology
- Infectious Diseases
- Public Health
Background:
- Enteric fever, caused by Salmonella typhi, has been prevalent in Rourkela for three years.
- A significant rise in multidrug-resistant Salmonella typhi strains has been observed, accounting for 16.1% of isolates in the last two years.
Purpose of the Study:
- To assess the antibiotic sensitivity patterns of Salmonella typhi isolates in Rourkela.
- To evaluate the prevalence of multidrug-resistant strains and identify effective treatment options.
Main Methods:
- Analysis of 5410 blood samples for Salmonella typhi detection.
- Antimicrobial susceptibility testing of isolated Salmonella typhi strains.
Main Results:
- 715 out of 5410 samples were positive for Salmonella typhi.
- Chloramphenicol sensitivity was high at 86.5%, and ceftriaxone showed 100% sensitivity.
- A low resistance rate of 2.5% was observed for ciprofloxacin.
Conclusions:
- Chloramphenicol and ceftriaxone are effective treatments against current Salmonella typhi strains in Rourkela.
- The emergence of multidrug resistance underscores the importance of antibiotic stewardship to prevent further resistance, particularly to ciprofloxacin.