Related Experiment Video
Updated: Aug 10, 2026

Methylated DNA Immunoprecipitation
Published on: January 2, 2009
Human morbid genetics revisited: relevance of epigenetics
1Neurogenetics Section Rm28, Centre for Addiction and Mental Health, 250 College Street, Ontario, Toronto, Canada M5T 1R8. arturas_petronis@camh.net
Abstract:
Identification of genes predisposing their carrier to complex diseases is a much more complicated task than finding genes involved in simple mendelian diseases. The slow progress in the genetic research of complex diseases could be due to limitations in the basic research strategy, which is almost exclusively orientated to the detection of disease-related DNA mutations or polymorphisms. I argue in this article that epigenetic misregulation of genes is more consistent with the features of complex diseases than is DNA sequence variation, and therefore that epigenetic factors could be important in understanding the origins of complex diseases.
Related Concept Videos
Epigenetic Regulation
Epigenetic Regulation
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Epigenetic Regulation
X-chromosome...
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Behavioral Genetics and Its Designs
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...

