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Published on: June 11, 2019
Prognostic role of stress thallium test in patients with significant coronary artery disease
C M Khanna1, A Mondal, G Khanna
1Department of Cardiology and Nuclear Medicine, Institute of Nuclear Medicine and Allied Sciences, Lucknow Road, Delhi-110 054.
Insights
Patients with coronary artery disease (CAD) and normal exercise thallium images have a favorable prognosis. This study confirms a low cardiac event rate in medically treated CAD patients with normal thallium scans.
Area of Science:
- Cardiology
- Nuclear Cardiology
- Diagnostic Imaging
Background:
- Normal exercise thallium-201 myocardial perfusion studies indicate a benign outcome.
- The prognostic value of normal exercise tomographic thallium images in patients with diagnosed coronary artery disease (CAD) requires further investigation.
Purpose of the Study:
- To assess the prognostic significance of normal exercise tomographic thallium imaging in medically managed patients with angiographically confirmed coronary artery disease (CAD).
Main Methods:
- Sixty-eight patients with significant angiographic CAD (Group A) and 70 patients with normal coronary arteries (Group B) were studied.
- Group A patients had varying degrees of vessel disease (one, two, or three vessels).
- Follow-up averaged 30 months.
Main Results:
- In Group A, only two cardiac events occurred (one cardiac death, one non-fatal myocardial infarction) over 30 months, with an event rate of 0.96% per year.
- Neither of the two patients experiencing events had ST segment depression during exercise.
- One patient in Group B (normal coronaries) experienced a non-fatal myocardial infarction.
Conclusions:
- Medically treated patients with coronary artery disease (CAD), including those with multivessel disease, exhibit a benign prognosis when exercise thallium imaging is normal.
- These findings have significant long-term implications for managing CAD patients and reducing healthcare costs.
Objective:
The benign outcome of patients with a normal exercise thallium-201 myocardial perfusion study has been well established. The aim of the study was to examine the prognostic implications of normal exercise tomographic thallium images in medically treated patients with angiographic evidence of coronary artery disease (CAD).
Methods:
There were 68 patients in Group A with significant angiographic CAD (54 male and 14 female) aged 52 +/- 12 years, 42 had one, 18 had two and eight had three vessel CAD (50% diameter stenosis 1, Group B had 70 patients who had normal coronary arteries at cardiac catheterization.
Results:
Exercise test was submaximal in 40 (50.82%) patients, ST segment depression during exercise occurred in 28 patients (41.1%) and angina during exercise in 24 patients (35.2%). Majority of patients (76.47%) were on anti-anginal therapy. During a mean follow up of 30 months only two patients had cardiac events in group A patient. One died of cardiac causes and one had non fatal myocardial infarction (event rate 0.96%/year). None of these 2 patients had positive ST response during exercise. In group B only one patient had non-fatal myocardial infarction.
Conclusion:
Medically treated CAD patients including those with multivessel CAD have a benign prognosis in the presence of normal exercise thallium images. These results have long term important implication in management of such patients and cost of health delivery.
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An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
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