[Transgenic plants in vaccinology]

Area of Science:

• Plant biotechnology
• Molecular biology
• Immunology

Context:

• Transgenic plants are increasingly recognized as a powerful platform for the biosynthesis of complex biological molecules.
• The production of pharmaceuticals and vaccines in plants, known as molecular farming, presents a cost-effective and scalable alternative to traditional methods.
• Challenges in traditional vaccine production necessitate exploration of novel and efficient systems.

Purpose:

• To discuss the application of transgenic plants for the production of antigens, antibodies, enzymes, and hormones.
• To evaluate the efficacy of transgenic plants as a system for producing bioactive molecules.
• To explore the prospects of using transgenic plants for mucosal immunization strategies.

Summary:

• Transgenic plants demonstrate high effectiveness in producing a variety of bioactive molecules, including antigens, antibodies, enzymes, and hormones.
• The study highlights the potential of molecular farming using genetically modified plants for pharmaceutical and industrial applications.
• Specific attention is given to the use of transgenic plants expressing viral and bacterial antigens for developing novel mucosal vaccines.

Impact:

• Transgenic plants offer a sustainable and economical approach to manufacturing essential biomolecules.
• This technology has the potential to revolutionize vaccine development, particularly for mucosal immunity.
• The findings support the advancement of plant-based biopharmaceuticals and immunotherapies.