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Updated: Aug 17, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Synthesis and preliminary antimicrobial screening of new benzimidazole heterocycles
H H Fahmy1, A El-masry, S H Ali Abdelwahed
1Therapeutical Chemistry Dept., National Research Centre, Dokki, Cairo, Egypt. hh_fahmy@usa.net
Abstract:
A series of 2-methylbenzimidazole incorporated to different heterocycles through ethyl or carbamoylethyl groups at position 1 of benzimidazole were synthesized. Also 3-(2-methylbenzimidazol-1-yl)propanoic acid hydrazide incorporated with semicarbazides and thiosemicarbazides were prepared. Moreover, the triazole 5e underwent Michael addition and alkylation reaction. Some of the newly synthesized compounds showed considerable antimicrobial activity against gram positive, negative bacteria and yeast.
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