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Gene2EST: a BLAST2 server for searching expressed sequence tag (EST) databases with eukaryotic gene-sized queries.
C Gemünd1, C Ramu, B Altenberg-Greulich
1European Molecular Biology Laboratory, Postfach 10.2209, 69012 Heidelberg, Germany.
Nucleic Acids Research
|March 10, 2001
Summary
Gene2EST is a new web server that helps researchers find expressed sequence tags (ESTs) for large, complex genes. It provides tools for efficient retrieval and analysis of EST data, aiding gene identification.
Area of Science:
- Genomics
- Bioinformatics
Background:
- Expressed sequence tags (ESTs) are valuable resources for gene expression studies.
- Current tools struggle to query large, highly spliced eukaryotic genes within EST databases.
Purpose of the Study:
- To introduce Gene2EST, a web server designed for efficient retrieval and analysis of ESTs matching large DNA queries.
- To provide researchers with tools for detailed gene study.
Main Methods:
- Gene2EST integrates RepeatMasker for repetitive sequence masking, BLAST2 for EST database searching, and Artemis for graphical display.
- The server is designed for querying large DNA sequences against EST databases.
Main Results:
- Gene2EST enables efficient retrieval of ESTs for large, highly spliced genes.
- The server facilitates subsequent analysis of retrieved ESTs.
Conclusions:
- Gene2EST addresses limitations of existing BLAST-based servers for large gene queries.
- This resource supports in-depth investigation of individual genes using EST data.