Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypertonic glucose preloads act preabsorptively to decrease intake in rats on postnatal day 18.

A Weller1, L Tsitolovskya, G P Smith

  • 1Developmental Psychobiology Laboratory, Department of Psychology, Bar Ilan University, Ramat Gan 52900, Israel.

Physiology & Behavior
|March 10, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neural and Behavioral Correlates of Individual Variability in Rat Helping Behavior: A Role for Social Affiliation and Oxytocin Receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same author

Unraveling the molecular basis of cannabidiolic acid methyl Ester's anti-depressive effects in a rat model of treatment-resistant depression.

Journal of psychiatric research·2024
Same author

Does the extent of neck surgery based on preoperative calcitonin level influence survival in medullary thyroid carcinoma: a retrospective tertiary centre experience.

Annals of the Royal College of Surgeons of England·2024
Same author

Surgical team simulation: assessing milestones, identifying gaps and enhancing active learning in military surgical residents.

BMJ military health·2023
Same author

Rare case of venous tumour thrombus from acinic cell carcinoma of the parotid gland.

Annals of the Royal College of Surgeons of England·2020
Same author

Airborne concentrations and chemical considerations of radioactive ruthenium from an undeclared major nuclear release in 2017.

Proceedings of the National Academy of Sciences of the United States of America·2019
Same journal

Post-weaning social isolation increases reward-seeking behavior in mice.

Physiology & behavior·2026
Same journal

DHEA model of PCOS selectively alters reproductive but not metabolic or behavioral phenotypes in female Long-Evans rats.

Physiology & behavior·2026
Same journal

Importance of Apparatus Scaling in Novel Object Recognition for Juvenile and Adult Rats.

Physiology & behavior·2026
Same journal

Chronic activity-based anorexia alters food intake microstructure in a time-dependent manner in female rats.

Physiology & behavior·2026
Same journal

Apelin receptor antagonist (ML221) facilitates memory reconsolidation in novel object recognition task.

Physiology & behavior·2026
Same journal

Are humans adapted to the world they have developed?

Physiology & behavior·2026
See all related articles

Preloads of glucose, not injections, significantly inhibit intake in young rats. This suggests a preabsorptive osmotic mechanism, not postabsorptive metabolism, controls early feeding behavior.

Area of Science:

  • Physiology
  • Neuroscience
  • Behavioral Science

Background:

  • Understanding factors that regulate feeding behavior is crucial for addressing appetite and metabolic disorders.
  • Early life feeding experiences can have long-lasting effects on metabolic health.

Purpose of the Study:

  • To investigate whether glucose preloads inhibit food intake via preabsorptive or postabsorptive mechanisms in developing rats.
  • To differentiate between osmotic and metabolic roles in glucose-induced satiety.

Main Methods:

  • 18-day-old rat pups underwent 24-hour food deprivation followed by a 30-minute feeding test.
  • Gastric preloads or intraperitoneal injections of glucose or 2-deoxy-D-glucose (2-DG) solutions were administered 5 minutes prior to the test.

Related Experiment Videos

Main Results:

  • Gastric glucose preloads more effectively reduced milk intake compared to intraperitoneal glucose injections.
  • A preload of 2-deoxy-D-glucose (2-DG), which impairs glucose utilization, similarly decreased intake, suggesting a non-metabolic effect.

Conclusions:

  • The findings support a preabsorptive osmotic mechanism, rather than a postabsorptive metabolic one, for glucose-induced intake inhibition in 18-day-old rats.
  • This suggests that osmotic cues in the stomach play a significant role in early satiety signaling.