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Interleukin-10 and the interleukin-10 receptor
K W Moore1, R de Waal Malefyt, R L Coffman
1Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc., Palo Alto, California 94304, USA. kevin.moore@dnax.org
Annual Review of Immunology
|March 13, 2001
Summary
Interleukin-10 (IL-10) is a key cytokine that regulates immune responses by limiting inflammation. This review explores IL-10
Area of Science:
- Immunology
- Molecular Biology
- Cell Biology
Background:
- Interleukin-10 (IL-10) is a multifunctional cytokine with broad effects on hemopoietic cells.
- Initially known for inhibiting T cells, monocytes, and macrophages, its functions are more diverse.
- IL-10 is crucial for regulating immune and inflammatory responses, with viral homologs highlighting its importance.
Purpose of the Study:
- To review current understanding of Interleukin-10 (IL-10) and its receptor.
- To highlight the in vivo functions of IL-10 in both health and disease.
- To explore IL-10's role in regulating diverse cell types and immune tolerance.
Main Methods:
- Literature review of findings on IL-10 and its receptor.
- Analysis of IL-10's regulatory roles in various immune and non-immune cells.
- Examination of IL-10's involvement in T regulatory cell differentiation and function.
Main Results:
- IL-10 primarily functions to limit and terminate inflammatory responses.
- It regulates the growth and differentiation of B cells, T cells, NK cells, and other cell types.
- IL-10 is critical for the development and function of T regulatory cells, impacting immune tolerance.
Conclusions:
- Interleukin-10 (IL-10) is a central regulator of immune homeostasis and inflammation.
- Its diverse functions extend to numerous cell types, influencing immune responses and tolerance.
- Understanding IL-10 and its receptor is vital for comprehending its role in health and disease.
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