[Increasing the non-specific resistance of animals to staphylococcus with official RNA preparations]

A single or double parenteral injection to mice of sodium nucleinate considerably elevated their nonspecific resistance to the virulent staphylococcus as soon as in four hours; the resistance remained marked for four days. Daily prolonged injection of the stimulant also proved to be very effective. In the simulated organism there occurred a significant depression of reproduction of the virulent staphylococci and an increase in the amount of phagocytic cells and their digestive activity. The latter served as a material basis for induced nonspecific resistance. The data obtained substantiated a possibility of using sodium nucleinate as an antibacterial nonspecific stimulant under clinical conditions.