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Updated: Jul 26, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
Published on: April 16, 2019
Interleukin-5: a drug target for allergic diseases
1Western Australian Institute for Medical Research & Curtin University of Technology, Level 5 MRF Building, Rear 50 Murray Street, Perth 6000, Australia. colin@cyllene.uwa.edu.au
Abstract:
There is a large body of evidence that eosinophils are a key component of the allergic response in asthma. Interleukin (IL) 5 is uniquely involved in the production of eosinophils, and with a variety of other cytokines and factors controls their activation, localization and survival. Thus, IL-5 is an important drug target for new anti-asthmatics. The routes to drug discovery are based on screens for inhibitors of IL-5 production, ligand antagonists, control of receptor expression and receptor activation. In this review, we will discuss specific targets and screening assays with examples of some of the compounds in development.
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