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Related Experiment Videos

ICSI and its outcome.

G D Palermo1, Q V Neri, J J Hariprashad

  • 1Center for Reproductive Medicine and Infertility, New York Presbyterian Hospital-Weill Medical College of Cornell University, 505 East 70th Street, New York, NY 10021-4872, USA.

Seminars in Reproductive Medicine
|March 21, 2001
PubMed
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Intracytoplasmic sperm injection (ICSI) is a safe and effective fertility treatment for male infertility. Neonates born from ICSI show normal development and congenital malformation rates comparable to conventional in vitro fertilization (IVF).

Area of Science:

  • Reproductive Medicine
  • Genetics
  • Obstetrics

Background:

  • Intracytoplasmic sperm injection (ICSI) is a widely used assisted reproductive technology for male infertility.
  • Concerns regarding ICSI safety persist due to its technique and sperm characteristics.
  • Previous studies indicate generally normal physical and mental development in ICSI-conceived children.

Purpose of the Study:

  • To evaluate the safety and outcomes of intracytoplasmic sperm injection (ICSI).
  • To analyze in vivo embryo development, obstetric outcomes, and congenital malformation rates in ICSI neonates.
  • To compare ICSI outcomes with conventional in vitro fertilization (IVF).

Main Methods:

  • Retrospective analysis of 3573 ICSI cycles from 2435 couples with male factor infertility.

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  • Data collection on clinical pregnancy, delivery rates, miscarriages, chromosomal abnormalities, and congenital malformations.
  • Obstetric and pediatric records were used for outcome assessment.

    • Main Results:

    • Clinical pregnancy rate was 44.8% with a 39.2% delivery rate per ICSI cycle.
    • Autosomal trisomy was found in 37 of 77 miscarriages; 29 pregnancies were terminated due to chromosomal abnormalities.
    • 1.8% of ICSI neonates (38/2059) had congenital abnormalities; rates were similar to conventional IVF.

    Conclusions:

    • Pregnancy course and congenital malformation rates following ICSI are comparable to conventional IVF.
    • ICSI is a safe and effective treatment option for male infertility.
    • The study supports the safety of ICSI for assisted reproduction.