Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vaccines and mucosal immunisation.

A W Cripps1, J M Kyd, A R Foxwell

  • 1Gadi Research Centre, Division of Science and Design, University of Canberra, ACT 2601, Canberra, Australia. cripps@scides.canberra.edu.au

Vaccine
|March 21, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Invasive Haemophilus influenzae Infections after 3 Decades of Hib Protein Conjugate Vaccine Use.

Clinical microbiology reviews·2021
Same author

The impact of the changing pneumococcal national immunisation program among older Australians.

Vaccine·2021
Same author

Increased intestinal permeability as a risk factor for type 2 diabetes.

Diabetes & metabolism·2016
Same author

Routine exercise alters measures of immunity and the acute phase reaction.

European journal of applied physiology·2014
Same author

Effects of probiotic supplementation over 5 months on routine haematology and clinical chemistry measures in healthy active adults.

European journal of clinical nutrition·2014
Same author

Probiotics, immunity and exercise: a review.

Exercise immunology review·2009

Developing effective mucosal vaccines remains challenging due to complex immune regulation and delivery issues. Advances in understanding mucosal immunity and new technologies promise future preventative and therapeutic mucosal vaccines.

Area of Science:

  • Immunology
  • Vaccinology

Background:

  • Early efforts in disease protection involved mucosal administration, leading to the birth of mucosal immunology.
  • Despite early promise, the development of efficacious mucosal vaccines has been hindered by regulatory complexities and delivery system limitations.

Purpose of the Study:

  • To review the historical challenges and future prospects of mucosal vaccine development.
  • To highlight the role of advanced antigen delivery and immunomodulation technologies.

Main Methods:

  • Review of historical literature on mucosal immunology and vaccine development.
  • Analysis of current challenges in mucosal immune regulation and antigen delivery.
  • Exploration of emerging technologies for vaccine design.

Related Experiment Videos

Main Results:

  • Few mucosal vaccines have demonstrated efficacy due to complex immune regulation and delivery obstacles.
  • Compartmentalization of the common mucosal immune system presents additional challenges for organ-specific vaccines.

Conclusions:

  • Despite historical hurdles, 21st-century knowledge of mucosal immunoregulatory mechanisms and novel technologies are poised to enable effective mucosal vaccine development.
  • Future mucosal vaccines hold potential for both preventative and therapeutic applications.