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Hidden scabies: diagnosis by polymerase chain reaction
G Bezold1, M Lange, R Schiener
1Department of Dermatology, University of Ulm, Oberer Eselsberg 40, 89081 Ulm, Germany.
The British Journal of Dermatology
|March 22, 2001
Summary
Diagnosing scabies can be challenging due to subtle symptoms. Polymerase chain reaction (PCR) offers a fast, sensitive method for detecting Sarcoptes scabiei DNA, aiding diagnosis and therapy monitoring.
Area of Science:
- Dermatology
- Molecular Biology
- Parasitology
Background:
- Scabies diagnosis is often difficult due to low mite burden or atypical presentations.
- Subtle or atypical skin manifestations can mimic other dermatological conditions, delaying accurate diagnosis.
Observation:
- A case of clinically atypical eczema was investigated.
- Polymerase chain reaction (PCR) was employed to detect Sarcoptes scabiei DNA in cutaneous scales.
Findings:
- PCR confirmed Sarcoptes scabiei DNA in the patient's scales before treatment.
- PCR results became negative two weeks post-therapy, indicating successful treatment.
Implications:
- PCR provides a rapid and highly sensitive diagnostic tool for scabies, especially in atypical or subclinical cases.
- This molecular method can facilitate effective therapy monitoring and potentially identify previously unrecognized scabies infections.