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A new flavone 2'-glucoside from Andrographis alata.
A G Damu1, B Jayaprakasam, D Gunasekar
1Natural Products Division, Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India.
Journal of Asian Natural Products Research
|March 23, 2001
Summary
A novel flavone glucoside was identified in the Andrographis alata plant. Its chemical structure was determined using spectral and chemical analysis methods.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Pharmacognosy
Background:
- Andrographis alata is a medicinal plant with a history of traditional use.
- Flavonoids and their glycosides are known for diverse biological activities.
- Isolation of new compounds from medicinal plants can lead to novel therapeutic agents.
Purpose of the Study:
- To isolate and characterize a new compound from Andrographis alata.
- To elucidate the chemical structure of the isolated compound.
- To contribute to the phytochemical knowledge of Andrographis alata.
Main Methods:
- Extraction of secondary metabolites from the whole plant of Andrographis alata.
- Chromatographic techniques for compound isolation.
- Spectroscopic methods (e.g., NMR, Mass Spectrometry) for structural elucidation.
- Chemical derivatization and analysis.
Main Results:
- A new flavone glucoside, 5,2',6'-trihydroxy-7-methoxyflavone 2'-O-beta-D-glucopyranoside, was successfully isolated.
- The structure of the new compound was definitively determined through comprehensive spectral and chemical analyses.
- This marks the first report of this specific flavone glucoside from this plant source.
Conclusions:
- The study successfully identified and characterized a novel flavone glucoside from Andrographis alata.
- The findings expand the understanding of the phytochemical profile of Andrographis alata.
- This new compound may serve as a lead for future pharmacological investigations.