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Published on: March 11, 2014
[The study of PCNA expression and AgNORs counting adult-onset laryngeal papilloma]
1Department of Otorhinolaryngology, Second Clinical Hospital, China Medical University, Shenyang 110003.
Unlabelled:
Avidin-Biotin-peroxidase Complex technique (ABC) and silver staining technique were used to study the relationship between proliferative activity and the biological status of adult-onset laryngeal papilloma. The proliferating index of PCNA positive cells was closely related to AgNORs count. The two indices were significantly different among these groups (P < 0.05).
Conclusion:
PCNA expression and AgNORs count are useful in distinguishing between benign and malignant laryngeal neoplasms, monitoring premalignancy and observing tumor biological activity.