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An Orthotopic Resectional Mouse Model of Pancreatic Cancer
Published on: September 24, 2020
Update on familial pancreatic cancer
H T Lynch1, R E Brand, C A Deters
1Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA. htlynch@creighton.edu
Current Gastroenterology Reports
|March 29, 2001
Summary
Approximately 5-10% of pancreatic cancer patients have a family history. Certain hereditary syndromes, like FAMMM with CDKN2A mutations, may indicate a new hereditary pancreatic cancer risk.
Area of Science:
- Oncology
- Genetics
- Hereditary Cancer Syndromes
Background:
- Pancreatic cancer affects 5-10% of patients with a family history.
- Hereditary pancreatic cancer is linked to specific genetic disorders.
- Familial atypical multiple mole melanoma (FAMMM) syndrome is one such disorder.
Purpose of the Study:
- To investigate the association between FAMMM syndrome, CDKN2A mutations, and hereditary pancreatic cancer.
- To identify potential new hereditary pancreatic cancer syndromes.
Main Methods:
- Review of familial pancreatic cancer cases.
- Analysis of individuals with FAMMM syndrome.
- Genetic testing for CDKN2A (p16) germline mutations.
Main Results:
- A subset of FAMMM kindred with CDKN2A mutations presented with both pancreatic cancer and malignant melanoma.
- This specific genetic profile suggests a potential new hereditary pancreatic cancer syndrome.
Conclusions:
- The CDKN2A germline mutation in FAMMM kindred may define a distinct hereditary pancreatic cancer syndrome.
- Further research is warranted to confirm this association and understand its implications.
