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Microbial transformation of hypoestenone
1Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. elsayed@yahoo.com
Journal of Natural Products
|March 30, 2001
Abstract:
Preparative-scale fermentation of hypoestenone (1) with Mucor ramannianus (ATCC 9628) has resulted in the isolation of 8(9)alpha-epoxyhypoestenone (2) and the new metabolites 8(9)alpha-epoxy-12,13-anhydrohypoestenone (3), 17-hydroxyhypoestenone (4), 13alpha,18-dihydroxyhypoestenone (5), and 13beta,18-dihydroxyhypoestenone (6). Structure elucidation of these metabolites was based primarily on 1D and 2D NMR analyses.