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[Recurrent coumarin necrosis in type II protein S deficiency]
H J Seyfarth1, A Siegemund, L Helling
1Medizinische Klinik und Poliklinik I, Universität Leipzig und Innere Abteilung des evangelisch-lutherischen Diakonissenkrankenhauses zu Leipzig.
VASA. Zeitschrift Fur Gefasskrankheiten
|April 4, 2001
Abstract:
Coumarin necrosis is a rare but clinical very important complication of therapy with coumarin derivatives. We report a patient with congenital protein S deficiency type II, who developed coumarin necrosis during stabilization of phenprocoumon. Diagnostic problems and therapeutic alternatives are discussed considering the recent literature.