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Related Experiment Videos

Naproxen availability from variable-dose and weight sustained-release tablets.

M H Amaral1, J M Lobo, D C Ferreira

  • 1Centro de Tecnologia do Medicamento, Faculty of Pharmacy of OPorto, Rua Aníbal Cunha, 164, 4050-Porto, Portugal.

Drug Development and Industrial Pharmacy
|April 9, 2001
PubMed
Summary
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Hydroxypropyl methylcellulose (HPMC) matrix tablets showed consistent naproxen release despite significant variations in tablet weight or drug dosage. This indicates robust drug availability regardless of formulation changes.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Materials Science

Background:

  • Hydroxypropyl methylcellulose (HPMC) is a common polymer used in extended-release drug formulations.
  • Controlling drug release from matrix tablets is crucial for therapeutic efficacy.
  • Variations in tablet weight and drug dose can potentially impact drug release profiles.

Purpose of the Study:

  • To evaluate the impact of weight variation and dose variation on naproxen release from HPMC matrix tablets.
  • To determine if significant changes in formulation parameters affect naproxen availability.
  • To assess the consistency of naproxen release under different manufacturing scenarios.

Main Methods:

  • Comparative dissolution testing of naproxen matrix tablets.

Related Experiment Videos

  • Formulations included tablets with a 2-fold weight variation (250 mg vs. 500 mg) at a constant dose.
  • Formulations also included tablets with a 2-fold dose variation (160 mg vs. 320 mg) at a constant weight.

    • Main Results:

    • A 2-fold weight variation in HPMC matrix tablets did not significantly alter naproxen release.
    • A 2-fold dose variation in HPMC matrix tablets did not significantly affect naproxen release.
    • Initial release rates were comparable between tablets of the same formulation and those with combined dose and weight variations.

    Conclusions:

    • Naproxen availability from HPMC matrix tablets is robust and not significantly affected by substantial weight or dose variations.
    • These findings suggest a reliable drug release mechanism within the HPMC matrix, offering formulation flexibility.
    • The study supports the potential for consistent therapeutic outcomes despite manufacturing variability in these specific tablet formulations.