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Sepsis and cholestasis.

R H Moseley1

  • 1Medical Service, Ann Arbor Veterans Affairs Health System, Michigan, USA. rmoseley@umich.edu

Clinics in Liver Disease
|April 9, 2001
PubMed
Summary
This summary is machine-generated.

Sepsis-associated cholestasis can cause jaundice in critically ill patients. Look for elevated bilirubin disproportionate to other liver enzymes as an early infection sign, even without typical symptoms.

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Area of Science:

  • Hepatology and Critical Care Medicine

Background:

  • Jaundice in hospitalized or critically ill patients necessitates a broad differential diagnosis.
  • Sepsis-associated cholestasis is a critical consideration in this patient population.

Purpose of the Study:

  • To highlight sepsis-associated cholestasis as a key differential diagnosis for jaundice.
  • To identify early warning signs of infection in critically ill patients.
  • To emphasize the importance of prompt recognition and intervention.

Main Methods:

  • Observational analysis of clinical presentation in sepsis-associated cholestasis.
  • Correlation of liver enzyme patterns with underlying infection.

Main Results:

  • Disproportionate elevation of serum bilirubin compared to alkaline phosphatase and aminotransferases is an early indicator.

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  • This pattern can occur even without fever, leukocytosis, or other overt signs of infection.

    • Conclusions:

    • Sepsis-associated cholestasis should be suspected in unexplained jaundice in critically ill patients.
    • Monitoring liver function tests can provide early warnings of occult infections.
    • Timely medical and surgical management can improve patient outcomes.