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In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease
Published on: July 19, 2024
Metabolic Dysfunction-Associated Steatotic Liver Disease and Viral Hepatitis
George Papatheodoridis1, Vasileios Lekakis1, Rafael Esteban2
1Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", Athens, Greece.
None:
Coexistence of metabolic dysfunction-associated steatotic liver disease and chronic hepatitis B (HBV) or C virus (HCV) infection is not uncommon. Hepatic steatosis without metabolic dysfunctions may have favorable effects on HBV increasing HBV surface antigen loss and preventing fibrosis progression, while steatohepatitis with metabolic dysfunctions increases the risk of fibrosis progression and hepatocellular carcinoma. In HCV genotype 3, hepatic steatosis is virus-induced and improves/resolves after viral clearance, while it is metabolic driven in other HCV genotypes persisting after viral clearance and contributing to ongoing liver injury. Treatment of metabolic parameters is mandatory for optimal management of patients with HCV.
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