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The lipid world.

D Segré1, D Ben-Eli, D W Deamer

  • 1Dept. of Molecular Genetics, Crown Human Genome Center, Weizmann Institute of Science, Rehovot 76100, Israel.

Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life
|April 12, 2001
PubMed
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The "Lipid World" theory proposes that self-assembling lipid molecules formed early life structures. These structures facilitated chemical reactions, leading to primitive life-like systems and offering insights into the origin of life.

Area of Science:

  • Origin of Life research
  • Biochemistry
  • Astrobiology

Background:

  • Abiotically formed bilayer membranes resemble modern cellular structures.
  • Compartmentalization of molecules in microenvironments is crucial for life's emergence.
  • Amphiphilic boundary structures are hypothesized to play a key role in abiogenesis.

Purpose of the Study:

  • To propose and explore the 'Lipid World' scenario as an early evolutionary step in the origin of cellular life.
  • To investigate the role of lipids and amphiphiles in self-organization and chemical activity.
  • To provide a theoretical framework and suggest experimental tests for the Lipid World model.

Main Methods:

  • Theoretical modeling of lipid self-organization into supramolecular structures (micelles, bilayers).

Related Experiment Videos

  • Analysis of chemical rate enhancements within lipid assemblies.
  • Computer simulations of mutual catalysis among amphiphiles within molecular assemblies.

    • Main Results:

    • Lipid assemblies can enhance chemical reaction rates, supporting energy-dependent synthetic reactions.
    • Mutual catalysis among amphiphiles can lead to self-sustaining, homeostatic systems.
    • Computer simulations suggest selective processes acting on amphiphilic assemblies.

    Conclusions:

    • The Lipid World model provides a plausible pathway for the origin of cellular life.
    • Amphiphilic self-organization and catalysis are key mechanisms for early life evolution.
    • The proposed framework is amenable to experimental validation.