The trigeminovascular system in bacterial meningitis
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Published on: April 1, 2014
O Hoffmann1, U Dirnagl, J R Weber
1Department of Neurology, Universitaetsklinikum Charité, Humboldt University Berlin, 10098 Berlin, Germany.
Abstract:
Headache as a cardinal symptom of acute meningitis reflects activation of trigeminal afferents from the meninges. With their perivascular endings, these fibers form the so-called trigeminovascular system (TVS), which releases proinflammatory neuropeptides upon nociceptive stimulation. In the present article, we review a role of the TVS in enhancing the early inflammatory response of bacterial meningitis. Furthermore, we discuss inhibition of neuropeptide release from the TVS using 5HT(1B/D) agonists as a potential new anti-inflammatory treatment strategy for early bacterial meningitis.
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