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[Heart failure: neurohumoral approach to treatment]
Insights
Heart failure, common in Western countries, involves abnormal defense system activation after heart injury. Recent research improves understanding of its pathophysiology and treatment, focusing on neurohumoral activation.
Area of Science:
- Cardiology
- Physiology
- Pathology
Context:
- Heart failure prevalence is rising in Western nations, linked to cardiovascular risk factors and an aging population.
- Increased survival rates in heart failure patients contribute to its growing prevalence.
- Cardiovascular aggression can trigger anomalous activation of defense systems, leading to heart failure.
Purpose:
- To review key aspects of neurohumoral activation in heart failure.
- To discuss the pathophysiological mechanisms underlying heart failure.
- To explore therapeutic implications related to neurohumoral pathways.
Summary:
- Heart failure is a prevalent condition often resulting from abnormal defense system responses post-cardiovascular insult.
- Investigational research over the past two decades has significantly advanced the understanding of heart failure pathophysiology, prevention, and treatment.
- This review focuses on neurohumoral activation in heart failure and its therapeutic relevance.
Impact:
- Enhanced understanding of heart failure pathophysiology.
- Identification of novel therapeutic targets within neurohumoral pathways.
- Improved strategies for heart failure prevention and management.
Abstract:
Heart failure is a frequent human disease, partly related to anomalous activation of the defense systems, following a cardiovascular aggression. Increases in the prevalence of heart failure have been observed in the so-called occidental culture countries, probably due to the increased prevalence of cardiovascular risk factors, ageing population, and heart failure patients' survival. During the last two decades, intensive investigation in the human and non-human set have contributed to better knowledge of the patophysiology, the prevention and the therapeutic approach of heart failure. The Authors reviewed on some aspects of the neurohumoral activation in heart failure, with therapeutic implications.