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Updated: Jul 30, 2026
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Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
Human histologic and histomorphometric analysis comparing OsteoGraf/N with PepGen P-15 in the maxillary sinus
J T Krauser1, M D Rohrer, S S Wallace
1Nova Southeastern University, Dept. of Periodontology, North Palm Beach, Florida, USA.
Implant Dentistry
|April 20, 2001
Summary
The study compared OsteoGraf/N with demineralized freeze-dried bone allograft to a new material, PepGen P-15, for sinus elevations. PepGen P-15 demonstrated faster bone regeneration for dental implants in atrophic maxilla.
Area of Science:
- Oral surgery
- Biomaterials science
- Regenerative medicine
Background:
- Anorganic bovine bone mineral (OsteoGraf/N) with demineralized freeze-dried bone allograft is a standard for sinus elevations.
- This composite graft material supports endosseous implant placement in atrophic maxilla.
Observation:
- A novel tissue-engineered bone graft material, PepGen P-15, was evaluated.
- PepGen P-15 combines OsteoGraf/N with a synthetic peptide (P-15) that promotes cell activity.
Findings:
- Radiographic, histologic, and histomorphometric analyses were performed.
- PepGen P-15 showed enhanced bone formation in a shorter time interval compared to the traditional composite graft.
Implications:
- PepGen P-15 offers a potentially superior alternative for sinus graft procedures.
- This could improve outcomes for dental implant rehabilitation in patients with severe maxillary atrophy.
