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Elastance-based control of a mock circulatory system.

L A Baloa1, J R Boston, J F Antaki

  • 1Department of Electrical Engineering, University of Pittsburgh, PA, USA.

Annals of Biomedical Engineering
|April 20, 2001
PubMed
Summary
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Researchers developed a novel control strategy for mock circulatory systems (MCS) to replicate the natural heart's Starling response. This new tool enables precise mimicry of cardiac conditions for evaluating devices like ventricular assist devices.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Physiology
  • Control Systems

Background:

  • The natural heart exhibits the Starling response, crucial for regulating cardiac output.
  • Existing mock circulatory systems (MCS) often lack sophisticated control to fully replicate this physiological behavior.
  • Accurate simulation of cardiac function is vital for developing and testing cardiac devices.

Purpose of the Study:

  • To develop and validate a new control strategy for an MCS that mimics the Starling response of the natural heart.
  • To implement Suga's elastance model within a nested feedback control system for precise cardiac function simulation.
  • To provide a tool for researchers to modify ventricular contractility and simulate various cardiac pathologies.

Main Methods:

  • Implementation of Suga's elastance model using nested elastance and pressure feedback control loops.

Related Experiment Videos

  • Development of an elastance control loop to calculate desired chamber pressure based on time-varying elastance and ventricular volume.
  • Integration of a pressure control loop to regulate chamber pressure according to the reference signal.
  • Validation through simulations and hardware testing on an MCS.

    • Main Results:

    • The developed elastance-based controller successfully mimicked the Starling response in the MCS.
    • The controller demonstrated appropriate responses to changes in preload, afterload, and contractility, similar to the natural heart.
    • Simulations and hardware tests confirmed the controller's ability to replicate physiological cardiac behavior.

    Conclusions:

    • A novel control strategy based on Suga's elastance model effectively mimics the natural heart's Starling response in an MCS.
    • The controller's ability to modify ventricular contractility offers a valuable tool for simulating cardiac pathologies.
    • This advancement facilitates the evaluation of cardiac devices, such as ventricular assist devices, under various physiological conditions.