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Related Experiment Videos

["Occult" ectopic ACTH secretion syndrome: a case report].

I García Puente1, V Sánchez Moro, P de Pablos Velasco

  • 1Sección de Endocrinología, Hospital Nuestra Señora del Pino, Las Palmas de Gran Canaria.

Anales De Medicina Interna (Madrid, Spain : 1984)
|April 27, 2001
PubMed
Summary

Occult ectopic ACTH syndrome, a rare cause of Cushing syndrome, involves excess ACTH from a non-pituitary source. A delayed diagnosis of an ACTH-secreting carcinoid tumor was made 20 years after initial treatment for Cushing syndrome.

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Area of Science:

  • Endocrinology
  • Oncology

Background:

  • Cushing syndrome is characterized by prolonged exposure to high cortisol levels.
  • ACTH-dependent Cushing syndrome can originate from the pituitary or ectopic sources.
  • Occult ectopic ACTH syndrome presents diagnostic challenges due to delayed identification of the ACTH source.

Observation:

  • A 55-year-old woman with Cushing syndrome underwent bilateral adrenalectomy.
  • Twenty years after treatment, an ACTH-secreting carcinoid tumor was discovered as the underlying cause.
  • This case highlights a prolonged, undiagnosed source of ectopic ACTH.

Findings:

  • The patient's condition was initially diagnosed as Cushing syndrome.
  • The definitive diagnosis of an ACTH-secreting carcinoid tumor was established two decades later.

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  • This underscores the potential for long latency periods in occult ectopic ACTH syndrome.

    • Implications:

    • Delayed diagnosis of ectopic ACTH sources can lead to prolonged hypercortisolemia and its complications.
    • This case emphasizes the importance of considering ectopic ACTH syndrome even after initial treatment for Cushing syndrome.
    • Improved diagnostic strategies are needed for early detection of non-pituitary ACTH sources.