Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Degradable and injectable poly(aldehyde guluronate) hydrogels for bone tissue engineering.

K Y Lee1, E Alsberg, D J Mooney

  • 1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

Journal of Biomedical Materials Research
|May 8, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hydrogels in Periodontal and Craniofacial Regeneration: Current Applications and Next-Generation Biomaterials.

Journal of periodontal research·2026
Same author

Anti-inflammatory therapy enables robot-actuated regeneration of aged muscle.

Science robotics·2023
Same author

Tough Adhesive Hydrogel for Intraoral Adhesion and Drug Delivery.

Journal of dental research·2023
Same author

Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair.

Science advances·2019
Same author

Bioinspired mechanically active adhesive dressings to accelerate wound closure.

Science advances·2019
Same author

FGF2 Enhances Odontoblast Differentiation by αSMA<sup>+</sup> Progenitors In Vivo.

Journal of dental research·2018
Same journal

Optimizing the tensile properties of polyvinyl alcohol hydrogel for the construction of a bioprosthetic heart valve stent.

Journal of biomedical materials research·2002
Same journal

Wear of conventional and cross-linked ultra-high-molecular-weight polyethylene acetabular cups against polished and roughened CoCr femoral heads in a biaxial hip simulator.

Journal of biomedical materials research·2002
Same journal

Immobilization of natural macromolecules on poly-L-lactic acid membrane surface in order to improve its cytocompatibility.

Journal of biomedical materials research·2002
Same journal

Light scattering and in vitro biocompatibility studies of poly (vinyl pyrrolidone) derivatives with amino-acid-dependent groups.

Journal of biomedical materials research·2002
Same journal

Immobilization of an oxalate-degrading enzyme on silicone elastomer.

Journal of biomedical materials research·2002
Same journal

An evaluation of the cytotoxic effects of orthodontic bonding adhesives upon a primary human oral gingival fibroblast culture and a permanent, human oral cancer-cell line.

Journal of biomedical materials research·2002
See all related articles

New injectable hydrogels made from poly(aldehyde guluronate) (PAG) show promise for bone tissue engineering. These degradable materials support cell growth and form mineralized bone after subcutaneous injection in mice.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Injectable hydrogels are desirable for bone tissue engineering, particularly in craniofacial applications, due to ease of delivery.
  • Alginate hydrogels are potential candidates but have limitations in mechanical properties and degradation control.

Purpose of the Study:

  • To synthesize and characterize novel injectable hydrogels with tunable mechanical stiffness and degradation rates.
  • To evaluate the cytocompatibility and bone-forming potential of these new hydrogels for bone tissue engineering.

Main Methods:

  • Synthesis of poly(aldehyde guluronate) (PAG) hydrogels crosslinked with adipic acid dihydrazide.
  • In vitro studies using MC3T3-E1 cells to assess cell adhesion and proliferation.

Related Experiment Videos

  • In vivo studies involving subcutaneous injection of PAG hydrogels with primary rat calvarial osteoblasts in mice.

    • Main Results:

    • The synthesized PAG hydrogels exhibited a wide range of mechanical stiffness and controllable degradation.
    • MC3T3-E1 cells demonstrated successful adhesion and proliferation on the PAG hydrogels in vitro.
    • In vivo implantation resulted in the formation of mineralized bone tissue within 9 weeks.

    Conclusions:

    • The novel PAG hydrogels offer tunable mechanical properties and degradation, addressing limitations of existing materials.
    • These injectable hydrogels support osteoblast function and promote bone regeneration in vivo.
    • PAG hydrogels show significant potential as an injectable delivery system for bone precursor cells in tissue engineering applications.