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Reducing mucus production after urinary reconstruction: a prospective randomized trial
J N'Dow1, C N Robson, J N Matthews
1Departments of Surgery, Physiological Sciences and Statistics, University of Newcastle upon Tyne, Newcastle upon Tyne, England.
The Journal of Urology
|May 9, 2001
Summary
Muco-regulatory drugs like N-acetylcysteine, aspirin, and ranitidine did not reduce mucus or urine viscosity in patients with urinary tract intestinal segments. These medications showed no benefit over placebo.
Area of Science:
- Urology
- Gastroenterology
- Pharmacology
Background:
- Intestinal segments used in urinary tract reconstruction continue to produce mucus.
- This mucus production can increase urine viscosity and potentially cause complications.
Purpose of the Study:
- To evaluate the effectiveness of muco-regulatory drugs in reducing mucus secretion and urine viscosity.
- Investigate the impact of N-acetylcysteine, aspirin, and ranitidine on patients with transposed intestinal segments.
Main Methods:
- Prospective randomized, double-blind, placebo-controlled crossover study.
- 12 ileal conduit and 31 bladder reconstruction patients participated.
- Urine samples analyzed for mucin and viscosity; quality of life surveys completed.
Main Results:
- Mucus production did not decrease over time in 67% of patients.
- Mucin constituted 3% of nondialyzable urinary material.
- No significant benefit of muco-regulatory agents over placebo was demonstrated.
Conclusions:
- N-acetylcysteine, aspirin, and ranitidine failed to reduce mucin production or urine viscosity.
- These drugs did not improve the quality of life for patients with transposed intestinal segments.