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Related Experiment Videos

Anabolic steroids increase exercise tolerance.

T Tamaki1, S Uchiyama, Y Uchiyama

  • 1Division of Human Structure and Function, Department of Physiology, Tokai University School of Medicine, Kanagawa 259-1193, Japan. tamaki@is.icc.u-tokai.ac.jp

American Journal of Physiology. Endocrinology and Metabolism
|May 15, 2001
PubMed
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Anabolic androgenic steroids (AAS) reduce muscle damage and enhance protein synthesis after weight lifting. AAS treatment also improves work capacity and muscle fatigue resistance in rats.

Area of Science:

  • Exercise Physiology
  • Muscle Biology
  • Pharmacology

Background:

  • Anabolic androgenic steroids (AAS) are performance-enhancing drugs.
  • Weight lifting causes muscle damage and affects protein synthesis.
  • The effects of AAS on muscle recovery post-exercise are not fully understood.

Purpose of the Study:

  • To investigate the influence of nandrolone decanoate (an AAS) on muscle recovery after weight lifting.
  • To assess thymidine and amino acid uptake, and myosin synthesis in rat skeletal muscles.
  • To evaluate the impact of AAS on muscle damage and fatigue resistance.

Main Methods:

  • Adult male rats were divided into Control and Steroid groups, with the Steroid group receiving nandrolone decanoate.
  • Exercise was induced via a single exhaustive bout of weight lifting.
Keywords:
Non-programmatic

Related Experiment Videos

  • [3H]thymidine and [14C]leucine labeling were used to measure cellular mitotic activity and amino acid uptake.
  • Serum creatine kinase (CK) activity was measured as an indicator of muscle damage.
  • In situ isometric mechanical properties of the plantaris muscle were assessed.

    • Main Results:

    • Steroid group rats lifted more weight and had lower CK levels post-exercise, indicating less muscle damage.
    • [3H]thymidine uptake was significantly lower in Steroid rats, suggesting reduced muscle damage.
    • [14C]leucine uptake was higher at rest and recovered faster post-exercise in Steroid rats, indicating enhanced protein synthesis.
    • Steroid group rats exhibited higher fatigue resistance in the plantaris muscle.

    Conclusions:

    • AAS treatment ameliorates muscle damage and enhances protein synthesis during recovery from weight lifting.
    • AAS treatment improves work capacity and muscle fatigue resistance.
    • These findings suggest potential benefits of AAS in muscle repair and performance, alongside reduced muscle damage.