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Androechin, a new chalcone glucoside from Andrographis echioides.
B Jayaprakasam1, D Gunasekar, K V Rao
1Department of Chemistry, Sri Venkateswara University, Tirupati, India.
Journal of Asian Natural Products Research
|May 18, 2001
Summary
Researchers isolated a new chalcone glucoside, androechin, and echioidinin 5-O-glucoside from Andrographis echioides. Androechin was identified as a specific trihydroxy-methoxychalcone glucoside through detailed analysis.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Organic Chemistry
Background:
- Andrographis echioides is a plant species with a history of traditional medicinal use.
- The isolation and characterization of bioactive compounds from medicinal plants are crucial for drug discovery.
- Chalcones and flavone glucosides are classes of natural products known for diverse biological activities.
Purpose of the Study:
- To isolate and identify chemical constituents from the whole plant of Andrographis echioides.
- To characterize a novel chalcone glucoside and a known flavone glucoside.
- To contribute to the phytochemical understanding of Andrographis echioides.
Main Methods:
- Phytochemical investigation involving extraction and isolation techniques.
- Spectroscopic analysis (e.g., NMR, Mass Spectrometry) for structural elucidation.
- Chemical methods for confirming the structure of isolated compounds.
Main Results:
- Isolation of a new chalcone glucoside, named androechin.
- Isolation of a known flavone glucoside, echioidinin 5-O-glucoside.
- Structural characterization of androechin as 2,2',6'-trihydroxy-4'-methoxychalcone 2'-O-beta-D-glucopyranoside.
Conclusions:
- The study successfully identified and characterized two glycosides from Andrographis echioides.
- Androechin represents a newly discovered natural product with potential for further investigation.
- This research expands the knowledge of the chemical diversity within the Andrographis genus.