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Transfer of normal 99mTc-ECD brain SPET databases between different gamma cameras
K Van Laere1, M Koole, J Versijpt
1Division of Nuclear Medicine, P7, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. koen.vanlaere@rug.ac.be
European Journal of Nuclear Medicine
|May 19, 2001
Summary
Accurate transfer of normal brain perfusion data between different gamma cameras is possible. This enables wider interdepartmental use, improving diagnostic capabilities for brain single-photon emission tomography (SPET).
Area of Science:
- Nuclear Medicine
- Neuroimaging
- Medical Physics
Background:
- A stereotactic, normal perfusion database is crucial for optimal clinical brain single-photon emission tomography (SPET).
- Accurate transferability of normal brain perfusion data between different gamma cameras is necessary for interdepartmental use.
- Existing normal perfusion databases may lack transferability due to variations in scanning equipment and resolution.
Purpose of the Study:
- To investigate the transferability of normal brain perfusion databases acquired on gamma cameras with different resolutions.
- To assess the accuracy of data transfer for creating a standardized, interdepartmentally usable normal perfusion database.
- To evaluate methods for optimizing data transfer and reducing variability between different imaging systems.
Main Methods:
- Acquired 101 brain SPET scans from 89 healthy adults using three multihead gamma cameras (Toshiba, Elscint Helix, Prism 3000) with varying resolutions.
- Standardized image processing, including filtered back-projection reconstruction and automated stereotactic registration to a common template.
- Analyzed 35 predefined volumes of interest (VOIs), applied smoothing to high-resolution data, and conducted Hoffman phantom measurements for camera characterization.
Main Results:
- Between-camera reproducibility was achieved with minimal variability (2.5% and 2.7%) after standardized processing.
- Partial volume effects varied based on VOI size after smoothing (-6.5% to 10%).
- Resolution adjustment combined with linear washout and Hoffman phantom-based correction significantly reduced between-camera variability.
Conclusions:
- Accurate transfer of normal brain perfusion data between multihead gamma cameras is feasible.
- Standardized processing and resolution correction enable widespread interdepartmental use of normal perfusion databases.
- This capability is expected to enhance the diagnostic accuracy of clinical brain perfusion SPET.