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[Plasmodium vivax: therapy update].

X Nicolas1, H Granier, J P Laborde

  • 1Service de Médecine interne, HIA Clermont-tonnerre, F 29240 Brest Naval. xfnicolas@hotmail.com

Presse Medicale (Paris, France : 1983)
|May 22, 2001
PubMed
Summary
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Plasmodium vivax malaria is widespread, causing recurrent illness. Emerging drug resistance necessitates new treatments, with tafenoquine showing promise as a primaquine alternative for recurrent malaria.

Area of Science:

  • Medical Parasitology
  • Infectious Diseases

Context:

  • Plasmodium vivax is the most prevalent malaria parasite globally.
  • Unlike P. falciparum, P. vivax causes benign tertian malaria with potential for early or late recurrence.
  • Emerging resistance to chloroquine and primaquine necessitates updated therapeutic strategies.

Purpose:

  • To review the global impact of Plasmodium vivax.
  • To discuss current and alternative treatment strategies for P. vivax malaria.
  • To highlight the emergence of drug-resistant strains and their implications.

Summary:

  • Chloroquine is the primary treatment for P. vivax, with alternatives like mefloquine, quinine, and halofantrine.
  • Recurrent P. vivax malaria requires a schizonticidal agent followed by primaquine, with adjusted dosages recommended.

Related Experiment Videos

  • Tafenoquine is a potential alternative to primaquine for treating recurrences, and its prophylactic role is under investigation.

    • Impact:

    • Addresses the challenge of widespread P. vivax malaria and its recurrent nature.
    • Highlights the critical issue of antimalarial drug resistance in P. vivax.
    • Informs therapeutic decisions for both primary and recurrent P. vivax infections.