NMR studies on three optical active drug molecules
E Bednarek1, J C Dobrowolski, A P Mazurek
1Drug Institute, 30/34 Chełmska Str. 00-725 Warsaw, Poland.
Abstract:
NMR spectroscopy is one of very few methods that enable deep insight into molecular structure and distinguishing of enantiomers. It usually requires the use of optically active agents that differentiate S and R forms through an interaction with studied molecule differentiate S and R forms. The aim of the present studies was to perform a preliminary NMR study on three chiral drugs: Fluoxetine hydrochloride, Ibuprofen, and Zolmitriptan by use of three optical solvating agents: R(-) 2,2,2-trifluoro-1-(9-anthryl)ethanol (I), (R)(+) 1,1'-bi-2-naphthol (II), and (S) tert-butyl-phenylphosphinothioic acid (III).
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