[Study on family aggregation of esophageal cancer in Linzhou city]
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1Department of Epidemiology, Fourth Military Medical University, Xi'an 710032, China.
Objective:
To investigate family aggregation of esophageal cancer (EC) in Linzhou city, a high risk area for EC.
Methods:
A hospital based case-control study were conducted, which included relatives of 118 EC cases and 168 controls. EC incidences in relatives of cases and controls were compared by chi 2 test and risk ratio (RR) was calculated. Heritability (h2) was estimated using the Falconer method.
Results:
EC incidence of case relatives was significantly higher than that in control relatives. The RR was 3.15 (2.15-4.61) in the first degree relatives and 1.87 (1.26-2.79) in the second degree relatives. The heritability was (53.39 +/- 5.93)% for the first degree relatives and (50.21 +/- 10.75)% for the second degree relatives, while the weighted h2 was (52.26 +/- 3.82)%.
Conclusion:
The genetic factor plays an important role the occurrence of EC in Linzhou city; however, environmental factors should not be ignored.
