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Neuropathogenesis of influenza virus infection in mice
1Department of Microbiology, Fukui Medical University School of Medicine, Fukui 910-1193, Japan.
Microbes and Infection
|May 30, 2001
Abstract:
The neurovirulent WSN strain of influenza A virus, introduced into the olfactory bulb of C57BL/6 mice, selectively attacks several brain nuclei which are highly implicated in the pathogenesis of neuropsychiatric disturbances. The virus-infected neurons are eradicated through apoptotic neurodegeneration. On the other hand, activated microglia serve the neuroprotection against virus infection.