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Related Experiment Videos

Perfusion imaging using dynamic arterial spin labeling (DASL).

E L Barbier1, A C Silva, S G Kim

  • 1Laboratory of Functional and Molecular Imaging and NIH MRI Research Facility, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1065, USA.

Magnetic Resonance in Medicine
|May 30, 2001
PubMed
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Dynamic arterial spin labeling (DASL) measures tissue perfusion and transit time. This study maps these parameters in rat brains under hypercapnia, revealing CO2 reactivity.

Area of Science:

  • Neuroimaging
  • Physiology
  • Magnetic Resonance Imaging

Background:

  • Dynamic arterial spin labeling (DASL) enables simultaneous measurement of tissue perfusion, transit time, and relaxation time.
  • DASL relies on analyzing tissue magnetization response to time-varying labeling functions.

Purpose of the Study:

  • To map brain perfusion and transit time in anesthetized rats using DASL.
  • To investigate the effects of graded hypercapnia on these parameters and compute CO2 reactivity maps.

Main Methods:

  • Utilized dynamic arterial spin labeling (DASL) combined with echo-planar imaging at 4.7 Tesla.
  • Acquired brain maps of perfusion and transit time in rats under varying arterial pCO2 levels.

Main Results:

Related Experiment Videos

  • Demonstrated variations in perfusion and transit time correlated with arterial pCO2.
  • Successfully computed CO2 reactivity maps based on the obtained data.

Conclusions:

  • DASL is effective for quantifying perfusion and transit time in vivo.
  • This technique provides insights into cerebrovascular CO2 reactivity in the anesthetized rat model.