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Updated: Feb 23, 2026

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Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
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Experience with 120 synthetic hydroxyapatite implants (FCI3)
1University of Ottawa Eye Institute, Ottawa, Ontario, Canada.
Ophthalmic Plastic and Reconstructive Surgery
|June 5, 2001
Summary
This study evaluated complications of the FCI3 synthetic hydroxyapatite implant, finding issues like discharge and implant exposure. Overall, complications were similar to other implants but with a lower exposure rate.
Area of Science:
- Ophthalmology
- Biomaterials Science
Background:
- Orbital implants are used to restore volume and contour after enucleation.
- Synthetic hydroxyapatite implants offer a potentially cost-effective alternative to traditional options.
Purpose of the Study:
- To assess the problems and complications associated with the FCI3 synthetic hydroxyapatite implant.
- To compare the complication profile of the FCI3 implant with existing literature.
Main Methods:
- A retrospective analysis of 120 patients who received the FCI3 implant over 4 years.
- Data collected included patient demographics, surgical details, implant size, follow-up duration, and encountered complications.
Main Results:
- Of 107 patients with adequate follow-up, 21 experienced discharge, and 3 had implant exposure.
- Peg-related complications occurred in 35.2% of patients, including discharge and pyogenic granuloma.
- The incidence of implant exposure was 2.8%, which is lower than reported for some other implants.
Conclusions:
- The FCI3 synthetic hydroxyapatite implant is a viable, less costly option for orbital reconstruction.
- Complication rates are comparable to other hydroxyapatite implants, with a notably lower exposure rate.
- The implant's slightly softer composition led to one instance of fracture under extreme pressure.

