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Related Experiment Videos

Coagulation point-of-care testing.

E M Van Cott1

  • 1Coagulation Laboratory, Division of Laboratory Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Clinics in Laboratory Medicine
|June 9, 2001
PubMed
Summary
This summary is machine-generated.

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Point-of-care testing for anticoagulant and platelet function monitoring requires further research. While activated clotting time (ACT) is widely used, its limitations are acknowledged, and other tests are still under evaluation for clinical utility.

Area of Science:

  • Medical Devices
  • Clinical Pathology
  • Hematology

Background:

  • Point-of-care (POC) testing offers potential advantages for monitoring anticoagulation and platelet function.
  • Current POC devices for prothrombin time (PT) need further evaluation for home self-monitoring of oral anticoagulant therapy.
  • Activated clotting time (ACT) is frequently used despite limitations, primarily due to the absence of cheaper, faster alternatives.

Purpose of the Study:

  • To review the current status and future directions of point-of-care testing in anticoagulation and platelet function monitoring.
  • To highlight the need for further research into the safety and efficacy of specific POC devices.
  • To discuss the clinical utility and limitations of existing POC testing methods.

Main Methods:

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  • Literature review of current point-of-care testing technologies.
  • Analysis of the availability, cost, and turnaround time of different testing methods.
  • Evaluation of the clinical application and defined roles of POC devices in patient care.

    • Main Results:

    • POC PT devices require more study for home use in oral anticoagulant therapy.
    • POC PTT testing is currently under evaluation.
    • ACT is commonly used despite limitations, largely due to lack of alternatives.
    • Several POC platelet function devices are available, but their clinical roles are not well-defined.

    Conclusions:

    • Further research is essential to establish the safety and efficacy of POC devices for anticoagulation and platelet function monitoring.
    • The clinical utility of POC platelet function devices remains to be clearly defined.
    • Despite limitations, ACT remains a commonly used POC test for coagulation monitoring.