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Cognitive function after systemic therapy for breast cancer.

J J Olin1

  • 1University of Vermont College of Medicine, Burlington, Vermont, USA. julie.olin@vtmednet.org

Oncology (Williston Park, N.Y.)
|June 9, 2001
PubMed
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Breast cancer survivors may experience cognitive impairment, including memory and attention issues, after chemohormonal therapy. Approximately one-third of patients in reviewed studies reported long-term cognitive dysfunction impacting quality of life.

Area of Science:

  • Oncology
  • Neuroscience
  • Survivorship Research

Background:

  • Cognitive function impairment is an underinvestigated area in breast cancer survivorship.
  • Breast cancer patients undergoing chemotherapy report memory, attention, and language difficulties.
  • Adjuvant chemohormonal therapy is a common treatment for breast cancer survivors.

Purpose of the Study:

  • To review published studies on cognitive dysfunction following adjuvant chemohormonal therapy in breast cancer.
  • To outline patient- and treatment-related factors influencing cognitive function.
  • To discuss the impact of cognitive impairment on survivors' quality of life and future therapy.

Main Methods:

  • Systematic review of four published studies documenting cognitive dysfunction.

Related Experiment Videos

  • Analysis of patient- and treatment-related factors.
  • Discussion of quality of life and future adjuvant therapy implications.

    • Main Results:

    • A subset of approximately one-third of participants experienced long-term cognitive impairment.
    • Cognitive deficits included issues with memory, attention span, concentration, and language skills.
    • Patient and treatment factors may influence the severity and duration of cognitive dysfunction.

    Conclusions:

    • Adjuvant chemohormonal therapy is associated with long-term cognitive impairment in a significant subset of breast cancer survivors.
    • Cognitive dysfunction negatively impacts survivors' quality of life.
    • There is a need for prospective longitudinal studies to document the neuropsychological sequelae of adjuvant chemohormonal therapy.