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Mechanisms of Ca(2+)-dependent transcription
1Departmento Biología Molecular y Celular, Centro Nacional de Biotecnología, CNB, CSIC Campus de Cantoblanco, 28049, Madrid, Spain.
Current Opinion in Neurobiology
|June 12, 2001
Abstract:
Ca(2+) has a central role in coupling synaptic activity and transcriptional responses. Recent studies have focused on Ca(2+)-dependent nuclear mechanisms that bring to the nucleosomal level cascades of events initiated in the submembranous space at the synapse. In addition, a new Ca(2+)-dependent interaction between a calcium sensor and DNA has been shown to regulate transcription directly.