Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmacology of erectile function and dysfunction.

K E Andersson1

  • 1Department of Clinical Pharmacology, University of Lund, Lund, Sweden. Karl-Erik.Andersson@klinfarm.lu.s

The Urologic Clinics of North America
|June 14, 2001
PubMed
Summary

Understanding the central and peripheral mechanisms of erectile function is key to developing new treatments for erectile dysfunction. Further research into neurotransmitters and penile tissue changes can lead to novel combination therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Calcium antagonists. Great tissue selectivity is the basis of their therapeutic use].

Lakartidningen·1997
Same author

Neurotransmitter release evoked by alpha-latrotoxin in the smooth muscle of the female pig urethra.

Naunyn-Schmiedeberg's archives of pharmacology·1997
Same author

NANC transmitters in the female pig urethra--localization and modulation of release via alpha 2-adrenoceptors and potassium channels.

British journal of pharmacology·1997
Same author

Morphological relations between haem oxygenases, NO-synthase and VIP in the canine and feline gastrointestinal tracts.

Journal of the autonomic nervous system·1997
Same author

Characterization of angiotensin II formation in human isolated bladder by selective inhibitors of ACE and human chymase: a functional and biochemical study.

British journal of pharmacology·1997
Same author

Stimulation of bladder activity by volume, L-dopa and capsaicin in normal conscious rats--effects of spinal alpha 1-adrenoceptor blockade.

Naunyn-Schmiedeberg's archives of pharmacology·1997

Area of Science:

  • Neuroscience
  • Pharmacology
  • Urology

Background:

  • The erectile process is centrally regulated by neurotransmitters like dopamine, serotonin, noradrenaline, and nitric oxide, along with peptides such as oxytocin and ACTH/alpha-MSH.
  • Peripheral neurotransmission, impulse propagation, and intracellular signal transduction in penile smooth muscles are not fully understood.

Purpose of the Study:

  • To explore central and peripheral regulatory systems involved in erectile function.
  • To identify potential therapeutic targets for erectile dysfunction (ED).
  • To investigate pathogenetic mechanisms underlying ED.

Main Methods:

  • Review of existing literature on central and peripheral regulation of erectile function.
  • Analysis of neurotransmitter and peptide systems involved in the erectile process.

Related Experiment Videos

  • Examination of penile tissue changes associated with ED.

    • Main Results:

    • Central neurotransmitter and peptide systems represent potential targets for novel ED pharmacotherapies.
    • Further investigation of peripheral mechanisms, including neurotransmission and signal transduction in penile smooth muscles, is warranted.
    • Understanding interactions between modulators may lead to combination therapies.

    Conclusions:

    • Elucidating central and peripheral mechanisms of erectile function is crucial for advancing ED treatment.
    • Targeting specific neurotransmitter systems and understanding penile tissue alterations can improve ED management and prevention.