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Related Concept Videos

Factors Affecting Body Temperature01:28

Factors Affecting Body Temperature

As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may  include:
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
Factors Affecting Drug Distribution: Miscellaneous Factors01:19

Factors Affecting Drug Distribution: Miscellaneous Factors

Drug distribution in the human body is a complex process influenced by various individual factors, including age, pregnancy, obesity, diet, body water composition, pH levels, and specific disease conditions.
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs01:21

Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs

A drug's physicochemical properties fundamentally influence its metabolism. For instance, a drug's molecular size and shape critically determine its interaction with enzymes and transporters — larger drugs may face difficulty reaching enzyme active sites, altering their metabolic pathways. The pKa of a drug, which establishes its ionization state, can impact its solubility and absorption, thereby influencing metabolism.
The drug's acidity or basicity is essential in determining the metabolic...
Factors Affecting Drug Biotransformation: Biological01:19

Factors Affecting Drug Biotransformation: Biological

Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...

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Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

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[A history of the electrocardiogram].

Dansk medicinhistorisk arbog·2002
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[Teaching medical history as a topic of an international congress. Report from a trip to Galveston, Texas, September 2000].

Lakartidningen·2001
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[Miniseries on hypothermia. Newly awaken interest for cold as a therapeutic tool].

Lakartidningen·2001
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[Hibernation--nature's model of resistance to ventricular fibrillation].

Lakartidningen·2001
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Survival and incidence of myocardial infarction in men with ambulatory ECG-detected frequent and complex ventricular arrhythmias. 10 year follow-up of the 'Men born 1914' study in Malmö, Sweden.

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The hibernator heart--nature's model of resistance to ventricular fibrillation.

Cardiovascular research·1996

Related Experiment Video

Updated: Jul 26, 2026

Measuring Skeletal Muscle Thermogenesis in Mice and Rats
07:56

Measuring Skeletal Muscle Thermogenesis in Mice and Rats

Published on: July 27, 2022

[Drugs affect and are affected by body temperature].

B W Johansson1

  • 1Hjärt-lungkliniken, sektionen för kardiologi, Universitetssjukhuset MAS, Malmö.

Lakartidningen
|June 14, 2001
PubMed
Summary

Drug effects on body temperature and the impact of cold on drug action are clinically significant. Researchers propose a "cold effect test" for new drugs, especially for hypothermic patients.

Area of Science:

  • Pharmacology
  • Physiology
  • Environmental Medicine

Context:

  • Body temperature regulation is influenced by ambient conditions and drug administration.
  • Hypothermia significantly impacts physiological and pharmacological processes.
  • Therapeutic hypothermia is increasingly used, highlighting the need to understand drug-cold interactions.

Purpose:

  • To review the multifaceted relationship between drugs and cold exposure.
  • To examine how hypothermia affects drug pharmacokinetics and pharmacodynamics.
  • To propose a new safety assessment for drugs concerning cold effects.

Summary:

  • Drugs can alter body temperature, while environmental temperature affects physiological and drug responses.
  • Hypothermia critically influences how the body processes and responds to medications (pharmacokinetics and pharmacodynamics).

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Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans
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Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans

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A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
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A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment

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Last Updated: Jul 26, 2026

Measuring Skeletal Muscle Thermogenesis in Mice and Rats
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Published on: July 27, 2022

Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans
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Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans

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A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
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A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment

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  • The study advocates for a 'cold effect test' before new drug approval, particularly for use in hypothermic states.

    • Impact:

    • Informs clinical practice regarding medication use in cold environments or during therapeutic hypothermia.
    • Highlights the need for specific drug testing to ensure patient safety under hypothermic conditions.
    • Contributes to the safe integration of hypothermia as a therapeutic strategy by addressing drug interactions.