Related Experiment Video
Updated: Jul 29, 2026

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
Published on: December 9, 2021
Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in
1Department of Pathology, Brigham and Women's Hospital and, Harvard Medical School, 221 Longwood Avenue, 02115, Boston, MA, USA
Abstract:
Neutrophil accumulation is a hallmark of immune complex-mediated inflammatory disorders. Current models of neutrophil recruitment envision the capture of circulating neutrophils by activated endothelial cells. We now demonstrate that immobilized immune complexes alone support the rapid attachment of neutrophils, under physiologic flow conditions. Initial cell tethering requires the low-affinity Fc gamma receptor IIIB (Fc gamma RIIIB), and the beta(2) integrins are additionally required for the subsequent shear-resistant adhesion. The attachment function of Fc gamma RIIIB may be facilitated by its observed presentation on neutrophil microvilli. In vivo, in a model of acute antiglomerular basement membrane nephritis in which immune complexes are accessible to circulating neutrophils, Fc gamma RIII-deficient mice had a significant reduction in neutrophil recruitment. Thus, the interaction of immune complexes with Fc gamma RIII may mediate early neutrophil recruitment in immune complex-mediated inflammation.
Related Concept Videos
Inflammation
Differentiation of Common Myeloid Progenitor Cells
Immunoglobulin-like Cell Adhesion Molecules
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Acute Inflammation I: Inflammatory Response
Acute Inflammation II: Cellular Phase
Hypersensitivity Reactions: Immune-Complex Reactions

